Vaccination against feline immunodeficiency virus using fixed infected cells
نویسندگان
چکیده
منابع مشابه
Feline leukemia virus and feline immunodeficiency virus.
Ophthalmic manifestations of FeLV or FIV infection can occur in all ocular tissues and may be manifestations of direct viral effects or secondary to viral-related malignant transformation. Additionally, the manifestations of common feline ophthalmic pathogens may be more severe and poorly responsive to therapy because of the immunosuppressive effects of FeLV or FIV infection. Prompt diagnosis o...
متن کاملFeline leukemia virus & feline immunodeficiency virus.
RISK OF INFECTION/EXPOSURE The risk of infection is higher in younger animals and cats that are in contact with multiple cats (strays). Generally, Feline Leukemia Virus (FeLV) is spread by casual contact between cats although as they age, resistance to infection develops. Feline Immunodeficiency Virus (FIV) is spread more commonly through bite wounds or through sexual behaviour. Exposure occurs...
متن کاملDNA vaccination affords significant protection against feline immunodeficiency virus infection without inducing detectable antiviral antibodies.
To test the potential of a multigene DNA vaccine against lentivirus infection, we generated a defective mutant provirus of feline immunodeficiency virus (FIV) with an in-frame deletion in pol (FIVDeltaRT). In a first experiment, FIVDeltaRT DNA was administered intramuscularly to 10 animals, half of which also received feline gamma interferon (IFN-gamma) DNA. The DNA was administered in four 100...
متن کاملVaccination with experimental feline immunodeficiency virus vaccines, based on autologous infected cells, elicits enhancement of homologous challenge infection.
Cats were vaccinated with fixed autologous feline immunodeficiency virus (FIV)-infected cells in order to present viral proteins to the immune system of individual cats in an MHC-matched fashion. Upon vaccination, a humoral response against Gag was induced. Furthermore, virus-neutralizing antibodies were detected in a Crandell feline kidney cell-based neutralization assay, but not in a neutrali...
متن کاملNeutralizing antibodies in cats infected with feline immunodeficiency virus.
Sera from cats experimentally infected with five isolates of feline immunodeficiency virus (FIV) from various geographical regions and from FIV enzyme-linked immunosorbent assay-seropositive field cats from four European countries neutralized the Petaluma strain of FIV (FIV-P), originally isolated in California, at high titers. In addition, FIV-P and a European isolate proved equally susceptibl...
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ژورنال
عنوان ژورنال: Veterinary Immunology and Immunopathology
سال: 1995
ISSN: 0165-2427
DOI: 10.1016/0165-2427(94)07013-w